Anaesthesia
Incidence and significance of orthostatic intolerance following general anesthesia:
http://www.cja-jca.org/cgi/content/full/48/suppl_1/A49
Orthostatic Hypotension Occurs Frequently in the First Hour After Anesthesia:
http://www.anesthesia-analgesia.org/cgi/content/abstract/98/1/40
Autonomic dysfunction – anaesthetic management:
http://www.anaesthetist.com/anaes/patient/ans.htm
Autoimmune
Immunization with neuronal nicotinic acetylcholine receptor induces neurological autoimmune disease:
http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=
12639997
Autonomic Nervous System
Dysautonomias: Clinical Disorders of the Autonomic Nervous System:
http://www.annals.org/cgi/content/full/137/9/753?ijkey=80ed406bab43870073a7b1a811e05be4555b2dcd
Organization of the Nervous System:
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/P/PNS.html
The Autonomic Nervous System by Dr. S. Bakewell
Addenbrooke’s Hospital, Cambridge:
http://www.nda.ox.ac.uk/wfsa/html/u05/u05_010.htm
Autonomic Regulation of Cardiovascular Function:
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=
neurosci.section.1414
Autonomic Regulation of the Bladder:
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=neurosci.section.1416
Pharmacology of the Autonomic Nervous System:
http://www.mc.vanderbilt.edu/gcrc/ad_center/2005Pharm501AutonomicsPDF.pdf
Autonomic Nervous System Disorders:
http://www.nlm.nih.gov/medlineplus/autonomicnervoussystemdisorders.html
Peripheral Neuropathies:
http://www.wfneurology.org/pdfs/SeminarsInClinicalNeurology/Munsat_chapter7.pdf
Baroreflex Failure
Four Faces of Baroreflex Failure:
http://circ.ahajournals.org/cgi/content/full/105/21/2518
Catecholamines
Catecholamine-related molecules and disorders:
http://neuromuscular.wustl.edu/lab/catechol.htm
Chiari malformation/spinal cord involvement
Watch a presentation by physicians at The Chiari Institute and NIH as they discuss the possible connection between POTS, Ehlers-Danlos syndrome and Chiari Malformation: (click on the Ehlers-Danlos National Foundation link)
http://www.thechiariinstitute.com/
Chiari 1 malformation redefined: Clinical and radiographic findings for 364 symptomatic patients:
http://www.chiariconnectioninternational.com/docs/ChiariI_Malformation_Redefined_Dr_Milhorat.pdf
Cerebral syncope in a patient with spinal cord injury:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=11990670&dopt=Abstract
Chiari, fibromyalgia, gastrointestinal problems, gulf war syndrome, multiple chemical sensitivities/environmental illness, orthostatic intolerance:
http://www.cfids.org/about-cfids/orthostatic-intolerance.asp
Sinus arrhythmia and pupil size in Chiari I malformation: evidence of autonomic dysfunction:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=8314116&dopt=Abstract
The Chiari Institute: (This information is provided for educational purposes only – The Dysautonomia Information Network is not promoting this clinic)
http://www.chiariinstitute.com/chiari_about.html
Autonomic nervous system disorders in 230 cases of basilar impression and arnold-chiari deformity:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=1494411&dopt=Abstract
Chiari I malformation as a cause of orthostatic intolerance symptoms: a media myth?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=11705431&dopt=Abstract
No increased herniation of the cerebellar tonsils in a group of patients with orthostatic intolerance:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd
=Retrieve&db=PubMed&list_uids=12598952&dopt=Abstract
Orthostatic hypotension following spinal cord injury: understanding clinical pathophysiology:
http://www.nature.com/sc/journal/v44/n6/full/3101855a.html
Chronic fatigue syndrome
Flexible Joints Associated with Chronic Fatigue Syndrome, Researchers Find:
http://www.hopkinschildrens.org/pages/news/pressdetails.cfm?newsid=109
The importance of orthostatic intolerance in the chronic fatigue syndrome:
http://www.ncf-net.org/library/orthostaticreview.htm
MEDLINEplus health information on chronic fatigue syndrome:
http://www.nlm.nih.gov/medlineplus/chronicfatiguesyndrome.html
Chronic fatigue syndrome: A hypothesis focusing on the autonomic nervous system:
http://cs.portlandpress.com/cs/096/0117/0960117.pdf
Diabetes and autonomic neuropathy
Chronic administration of pharmacologic doses of vitamin E improves the cardiac autonomic nervous system in patients with type 2 diabetes:
http://www.ajcn.org/cgi/content/full/73/6/1052
Value of scintigraphy using meta-iodo-benzyl-guanidine (MIBG) in the investigation of cardiac autonomic neuropathy in diabetic patients. Comparison with Ewing tests:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=9404408&dopt=Abstract
Abnormal cardiovascular reflexes in juvenile diabetics as preclinical signs of autonomic neuropathy:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=7346309&dopt=Abstract
Response of the autonomous nervous system of the heart in diabetes mellitus:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=529862&dopt=Abstract
MEDLINEplus health information on diabetes:
http://www.nlm.nih.gov/medlineplus/diabetes.html
Ehlers-Danlos Syndrome
eMedicine Journal, Ehlers-Danlos syndrome:
http://author.emedicine.com/ped/topic654.htm
Ehlers-Danlos National Foundation:
http://www.ednf.org/
Fibromyalgia
National Fibromyalgia Research Association:
http://www.nfra.net/default.htm
MEDLINEplus health information on fibromyalgia:
http://www.nlm.nih.gov/medlineplus/fibromyalgia.html
Alternative treatments for fibromyalgia:
http://www.worldstar.com/~carltown/path2well/fibro1.htm
A review of fibromyalgia:
http://www.ajmc.com/files/articlefiles/AJMCnovNampiaparampil794.pdf
Elusive syndromes: Treating the biologic basis of fibromyalgia and related syndromes:
http://www.ccjm.org/pdffiles/Clauw1001.pdf
Hormones
Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women:
http://circ.ahajournals.org/cgi/content/abstract/101/8/862
Hypovolemia
Hypovolemia in syncope and orthostatic intolerance role of the renin-angiotensin system:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=9274896&dopt=Abstract
Is this patient hypovolemic?
http://jama.ama-assn.org/cgi/content/abstract/281/11/1022
Idiopathic hypovolemia: a self perpetuating autonomic dysfunction?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=9869552&dopt=Abstract
Lipodystrophy
Partial lipodystrophy in a boy:
http://www.indianpediatrics.net/jan2000/case3.htm
Lipodystrophy, generalized:
http://www.emedicine.com/med/topic3523.htm
Medications
Web Site for cardiovascular and autonomic pharmacology:
https://courses.washington.edu/chat543/cvans/vlab/index.html
Drug protects against nervous system failure:
http://www.news.harvard.edu/gazette/1997/04.17/DrugProtectsAga.html
Treatment of orthostatic hypotension with erythropoietin:
http://content.nejm.org/cgi/content/absract/329/9/611
Effects of long-term clonidine administration on the hemodynamic and neuroendocrine postural responses of patients with dysautonomia:
http://www.chestjournal.org/cgi/reprint/83/2/436
Cardiac vagal response to water ingestion in normal human subjects:
http://cs.portlandpress.com/cs/103/0157/cs1030157.htm
Mitochondrial disease and dysautonomia
Mitochondrial cytopathy in adults: what we know so far:
http://www.ccjm.org/pdffiles/COHEN701.PDF
Mitochondrial encephalomyopathies presenting with features of autonomic and visceral dysfunction:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=8736411&dopt=Abstract
A case of mitochondrial encephalomyopathy with peripheral neuropathy and autonomic symptoms:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=7605684&dopt=Abstract
Neurologic presentations of mitochondrial disorders
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=10641610&dopt=Abstract
Mitral valve prolapse
Mitral valve prolapse:
http://www.consciouschoice.com/1995-98/cc093/hmd093.html
The phenomenon of dysautonomia and mitral valve prolapse:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=8003350&dopt=Abstract
Exercise response in young women with mitral valve prolapse:
http://www.chestjournal.org/cgi/reprint/96/5/1076
Mitral Valve Prolapse in Active Patients: Recognition, Treatment, and Exercise Recommendations:
http://www.physsportsmed.com/issues/1996/07_96/joy.htm
Outlook
Impaired autonomic function is associated with increased morality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: The Hoorn study:
http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?
http://care.diabetesjournals.org/cgi/pmidlookup?view=full&pmid=11574444
Orthostatic hypotension in organic dementia: relationship between blood pressure, cortical blood flow and symptoms:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=8924753&dopt=Abstract
Neurocardiovascular instability, hypotensive episodes, and MRI lesions in neurodegenerative dementia:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=10818535&dopt=Abstract
Orthostatic hypotension in Alzheimer’s disease: result or cause of brain dysfunction?
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=10476310&dopt=Abstract
Orthostatic hypotension as a risk factor for stroke:
http://stroke.ahajournals.org/cgi/pmidlookup?view=full&pmid=11022055
Organizations
American Dysautonomia Institute:
http://www.adiwebsite.org/
National Dysautonomia Research Foundation:
http://www.ndrf.org/
Dysautonomia Youth Network of America (DYNA) (devoted to youth with dysautonomia)
www.dynakids.org
STARS – syncope trust and reflex anoxic seizures:
www.stars.org.uk
Pediatric Network
www.pediatricnetwork.org
Orthostatic hypotension
Treatment of orthostatic hypotension:
http://www.neuropathymd.org/pdf/35/Treatment%20of%20Orthostatic%20
Hypotension.pdf
Assessment of orthostatic blood pressure: measurement technique and clinical applications:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=10071663&dopt=Abstract
Paraneoplastic syndromes
Neurological paraneoplastic syndromes producing weakness or sensory loss:
http://www.dcmsonline.org/jax-medicine/2000journals/august2000/paraneoplastic.htm
Reversible paraneoplastic encephalomyelitis associated with a benign ovarian teratoma:
http://www.cjns.org/26novtoc/reversible.html
Paraneoplastic autonomic neuropathy:
http://www.emedicine.com/NEURO/topic298.htm
Immunological and endocrinological abnormalities in paraneoplastic disorders with involvement of the autonomic nervous system:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=9241563&dopt=Abstract
Pheochromocytoma
Biochemical diagnosis of pheochromocytoma:
http://www.angelfire.com/hi/Pheochromocytoma/biodiag.html
Pheochromocytoma:
http://author.emedicine.com/PED/topic1788.htm
Pheochromocytoma support site: (with lots of links)
http://members.aol.com/ThreePeb/indexpheo1.html
MEDLINEplus health information on pheochromocytoma:
http://www.nlm.nih.gov/medlineplus/pheochromocytoma.html
Germ-line mutations in nonsyndromic pheochromocytoma:
http://content.nejm.org/cgi/content/abstract/346/19/1459
Porphyria
Diagnosis and management of porphyria:
http://bmj.bmjjournals.com/cgi/content/full/320/7250/1647
Merck Manual: porphyrias:
http://www.merck.com/mrkshared/mmanual_home2/sec12/ch160/ch160a.jsp
Sex
Autonomic Regulation of Sexual Function:
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&
rid=neurosci.section.1418
Neurogenic Sexual Dysfunction in Man and Women:
http://www.wfneurology.org/docs/pdf/Munsat_chapter4.pdf
Sleep
Sleep-disordered breathing and hypotension:
http://ajrccm.atsjournals.org/cgi/content/full/164/7/1242
Syringomyelia
NINDS syringomyelia information page:
http://www.ninds.nih.gov/disorders/syringomyelia/syringomyelia.htm
Postural tachycardia syndrome in syringomyelia: response to fludrocortisone and beta-blockers:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=11710800&dopt=Abstract
Involvement of the autonomic nervous system in patients with syringomyelia – a study with the sympathetic skin response:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=8654321&dopt=Abstract
Hyperhidrosis as the presenting symptom in post-traumatic syringomyelgia: (hyperhidrosis is excessive sweating)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=8090551&dopt=Abstract
Cardiovascular reflexes in syringomyelia:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=
Retrieve&db=PubMed&list_uids=7139257&dopt=Abstract
MEDLINEplus health information on syringomyelia:
http://www.nlm.nih.gov/medlineplus/syringomyelia.html
Tests/management
Assessment: Clinical Autonomic Testing:
http://aan.com/professionals/practice/pdfs/pdf_1995_thru_1998/1996.46.873.pdf
Testing the autonomic nervous system:
http://www.iasp-pain.org/TC98NovDec.html
The fainting patient: value of the head-upright tilt-table test in adult patients with orthostatic intolerance:
http://www.cmaj.ca/cgi/content/full/164/3/372
Autonomic diseases: management:
http://jnnp.bmjjournals.com/cgi/content/full/74/suppl_3/iii42
Autonomic diseases: clinical features and laboratory evaluation:
http://jnnp.bmjjournals.com/cgi/content/full/74/suppl_3/iii31
Syncope Care & Treatment:
http://my.clevelandclinic.org/heart/disorders/electric/syncope.aspx
